Anti-GFAP Rabbit mAb - Astrocyte Marker

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市场价（人民币）

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MAN5806

Anti-GFAP Rabbit mAb - Astrocyte Marker

50ul

1800.00

In stock

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产品概述
Background The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments, and microtubules. Major types of intermediate filaments are specifically expressed in particular cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape. In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes. In addition, GFAP intermediate filaments are also present in nonmyelin-forming Schwann cells in the peripheral nervous system. Concentration 1mg/ml Reactivity Human, Mouse, Rat, Monkey Tested applications Western Blotting 1:1000 Immunoprecipitation 1:200 Immunohistochemistry (Paraffin) 1:500 Optimal dilutions/concentrations should be determined by the end user. Specificity This antibody detects endogenous levels of total GFAP protein. Immunogen Full length native protein (purified) corresponding to Human GFAP. Host Rabbit Isotype Rabbit IgG Form Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol，0.02% Sodium Azide Storage instruction Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle. For Research Use Only. Not For Use In Diagnostic Procedures.

产品概述

Background

The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments, and microtubules. Major types of intermediate filaments are specifically expressed in particular cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape. In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes. In addition, GFAP intermediate filaments are also present in nonmyelin-forming Schwann cells in the peripheral nervous system.

Concentration

1mg/ml

Reactivity

Human, Mouse, Rat, Monkey

Tested applications

Western Blotting 1:1000

Immunoprecipitation 1:200

Immunohistochemistry (Paraffin) 1:500

Optimal dilutions/concentrations should be determined by the end user.

Specificity

This antibody detects endogenous levels of total GFAP protein.

Immunogen

Full length native protein (purified) corresponding to Human GFAP.

Host

Rabbit

Isotype

Rabbit IgG

Form

Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol，0.02% Sodium Azide

Storage instruction

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.

For Research Use Only. Not For Use In Diagnostic Procedures.

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