氢化可的松 Hydrocortisone

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MG83217

氢化可的松 Hydrocortisone

50-23-7

800.00

In stock

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产品概述
Biotechnology Grade, Purity > 99% Molecular Weight : 362.46 Molecular Formula : C21H30O5 Description Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid receptor (GR) . Glucocorticoids as hydrocortisone and methylprednisolone are known as ABCB1 substrates. Hydrocortisone was observed to significantly decrease co-culture-induced p38 MAPK expression in bothpancreatic acinar cells (PACs) and stellate cells (PSCs). The 10 nM concentration of hydrocortisone used in the study was significantly lower than the lowest normal serum cortisol level of approximately 140 nM in human sera. The Hydrocortisone treatment alleviates sepsis-induced acute kidney injury in mice through HSF-1-mediated transcriptional suppression of XPO1. Hydrocortisone (70, 140 or 200 mg/kg) treated mice with i.p. injection of did not change either number or percentage of bone marrow B cell subsets. After 24 h of a single i.p. injection of 140 mg/kg of hydrocortisone a reduction in thymus weight and number of thymocytes could be observed. When mice were i.p. injected with hydrocortisone for three consecutive days, there was a depletion of the percentage and number of progenitors and lymphocytes. Storage condition 2-8℃ For Research Use Only. Not For Use In Diagnostic Procedures.

产品概述

Biotechnology Grade, Purity > 99%

Molecular Weight : 362.46

Molecular Formula : C21H30O5

Description

Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid receptor (GR) . Glucocorticoids as hydrocortisone and methylprednisolone are known as ABCB1 substrates.

Hydrocortisone was observed to significantly decrease co-culture-induced p38 MAPK expression in bothpancreatic acinar cells (PACs) and stellate cells (PSCs). The 10 nM concentration of hydrocortisone used in the study was significantly lower than the lowest normal serum cortisol level of approximately 140 nM in human sera.

The Hydrocortisone treatment alleviates sepsis-induced acute kidney injury in mice through HSF-1-mediated transcriptional suppression of XPO1. Hydrocortisone (70, 140 or 200 mg/kg) treated mice with i.p. injection of did not change either number or percentage of bone marrow B cell subsets. After 24 h of a single i.p. injection of 140 mg/kg of hydrocortisone a reduction in thymus weight and number of thymocytes could be observed. When mice were i.p. injected with hydrocortisone for three consecutive days, there was a depletion of the percentage and number of progenitors and lymphocytes.

Storage condition

2-8℃

For Research Use Only. Not For Use In Diagnostic Procedures.

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