绿脓菌素 Pyocyanin - 迈基生物

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绿脓菌素 Pyocyanin

产品货号

产品名称

CAS号

包装

市场价（人民币）

库存状态

MLJ10992

绿脓菌素 Pyocyanin

85-66-5

10mg

2400.00

In stock

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产品概述
Synonym : 5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin Molecular Weight : 210.23 Molecular Formula : C13H10N2O Purity (HPLC) ≥ 98.0% Description Pyocyanin (PCN) is a blue redox-active secondary metabolite produced by Pseudomonas aeruginosa. PCN is readily recovered in large quantities in sputum from patients patients infected with P. aeruginosa. PCN interferes with multiple cellular functions. In vitro : Pyocyanin induced a time- and concentration-dependent acceleration of neutrophil apoptosis. Treatment with 50 μM pyocyanin resulted in a 10-fold induction of apoptosis at 5h(p < 0.001). The concentration 50 (μM) has been documented in sputum from patients colonized with P. aeruginosa. Pyocyanin showed no effects on the apoptosis of monocyte-derived macrophages or airway epithelial cells at time points up to 24 h. Pyocyanin resulted in gradual onset of slowing and ultimate widespread ciliostasis with epithelial disruption. In vivo : In a murine model of acute pneumonia, pyocyanin production by P. aeruginosa suppressed the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and by reducing local inflammation. Intratracheal instillation of wild-type and pyocyanin-deficient strains of P. aeruginosa caused a rapid increase in bronchoalveolar lavage neutrophil counts up to 18 h after infection. In wild-type infection, the number of neutrophil declined steadily. neutrophil numbers increased up to 48 h in mice infected with pyocyanin-deficient P. aeruginosa. Pyocyanin production was associated with reduced bacterial clearance from the lungs. The concentration of potent neutrophil chemokines (MIP-2, KC) and cytokines (IL-6, IL-1β) were significantly lower in wild-type when compared with that of phenazine-deficient strain-infected mice at 18 h. Pyocyanin (600 ng) resulted in 60% reduction in tracheal mucus velocity at 3 h, and no recovery occurred. Storage condition −20°C For Research Use Only. Not For Use In Diagnostic Procedures.

产品概述

Synonym : 5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

Molecular Weight : 210.23

Molecular Formula : C13H10N2O

Purity (HPLC) ≥ 98.0%

Description

Pyocyanin (PCN) is a blue redox-active secondary metabolite produced by Pseudomonas aeruginosa. PCN is readily recovered in large quantities in sputum from patients patients infected with P. aeruginosa. PCN interferes with multiple cellular functions.

In vitro : Pyocyanin induced a time- and concentration-dependent acceleration of neutrophil apoptosis. Treatment with 50 μM pyocyanin resulted in a 10-fold induction of apoptosis at 5h(p < 0.001). The concentration 50 (μM) has been documented in sputum from patients colonized with P. aeruginosa. Pyocyanin showed no effects on the apoptosis of monocyte-derived macrophages or airway epithelial cells at time points up to 24 h. Pyocyanin resulted in gradual onset of slowing and ultimate widespread ciliostasis with epithelial disruption.

In vivo : In a murine model of acute pneumonia, pyocyanin production by P. aeruginosa suppressed the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and by reducing local inflammation. Intratracheal instillation of wild-type and pyocyanin-deficient strains of P. aeruginosa caused a rapid increase in bronchoalveolar lavage neutrophil counts up to 18 h after infection.

In wild-type infection, the number of neutrophil declined steadily. neutrophil numbers increased up to 48 h in mice infected with pyocyanin-deficient P. aeruginosa. Pyocyanin production was associated with reduced bacterial clearance from the lungs. The concentration of potent neutrophil chemokines (MIP-2, KC) and cytokines (IL-6, IL-1β) were significantly lower in wild-type when compared with that of phenazine-deficient strain-infected mice at 18 h. Pyocyanin (600 ng) resulted in 60% reduction in tracheal mucus velocity at 3 h, and no recovery occurred.

Storage condition

−20°C

For Research Use Only. Not For Use In Diagnostic Procedures.

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